ea0029s56.2 | Pituitary development transcription factors: stem cells and beyond | ICEECE2012
Rhodes S.
, Malik R.
, Park S.
, Prince K.
Our goal is to better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases in order to facilitate improved diagnosis, treatment, and family counselling. LIM-homeodomain transcription factors regulate many aspects of development and mutations in the genes that encode these regulatory proteins are associated with several diseases. The LHX3 LIM-homeodomain protein is critical for pituitary gland organogenesis and some nervous s...